In your opinion, can the idea of God become so generalized that God itself is essentially irrelevant, or so general as to be a meaningless idea?
For instance, I am thinking in particular of Albert North Whitehead's claim that, "If God is everything in general, God is nothing in particular?"
The mystical tradition represented by your avatar picture would indeed say that God is, in fact, Nothing, that pure nothingness -- no-thing-ness -- is the root of all being. God is in fact "irrelevant" and "meaningless" because the imputation of "relevance" and "meaning" to the Infinite is impossible. Such concepts would by definition limit that which cannot be limited.
The rub, though, is that we are not separate or distinct from this Nothing, but in fact this Nothing is the source of all things, including us. The paradox is that the irrelevant and meaningless God is at the same time infinitely relevant and infinitely meaningful when perceived through us.